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. 2018 Jul 6;8:10240. doi: 10.1038/s41598-018-28551-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of RAD288 and RAD289 on morphology of mOECs. (a) Representative images of mOECs after drug exposure. Images were segmented with Harmony software using Find Cytoplasm method. Scale bar = 100 µm. (b) Nucleus area of mOECs after treatment with several concentrations of RAD288. (c) Nucleus area of mOECs after treatment with a range of concentrations of RAD289. (d) Cytoplasm area of mOECs after treatment with several concentrations of RAD288. (e) Cytoplasm area of mOECs after treatment with a range of concentrations of RAD289. Negative control (0.2% DMSO) and positive control (1% G5 Supplement) were used. Triplicate wells were used in three separate experiments. Results represent the mean +/− SEM. ***p < 0.001, **p < 0.01, *p < 0.05, Student’s t-test.