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. 2018 Jul 6;8:10272. doi: 10.1038/s41598-018-28538-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GABA levels are positively correlated with GRP levels in patients with NE markers. (a) A positive correlation between GABA and GRP levels was found in PCa patients (r = 0.894; p = 0004; n = 10), and when patients were separated, PCa-NE patients had a strong positive correlation (r = 0.961; p = 0.03; n = 4). (b–d) Relative AR, ENO2 (*p < 0.05), GABBR1 (**p < 0.001) gene expression in BPH vs. PCa and BPH vs. PCa-NE, respectively. AR mRNA levels were not significantly different between groups. (e) PCA3 mRNA levels were significantly higher in PCa patients compared to BPH patients (*p < 0.05).