Fig. 3.

a Calibration of IBIS-RET for estimates of invasive BC in women with LCIS diagnosed at <50 years (cut-off: <18.8%, ≥18.8%–<23.5%). b Calibration of IBIS-RET for estimates of invasive BC in women with LCIS diagnosed at >=50 years (cut-off: ≥18.8%–<23.5%, ≥23.5%). The assigned line (triangle symbol) is the mean 10-year predicted risks of the IBIS-RET for that tertile (<18.8%, ≥18.8%-<23.5%, ≥23.5%). The observed line (square symbol) is the estimates of 10-year breast cancer probabilities based on the womens’ observed breast cancer status, and the bars denote 95% confidence intervals for the observed risk