Fig. 2.
Chemotherapy-resistant MPM cells are hypersensitive to ER stress. a Viability of 2D and 3D cells (MESO-1) after treated with chemo (1 μM cisplatin + 1 μM MTA) or the indicated agents for 72 h. Data are presented as mean ± s.d. (n = 3). *P < 0.05, ** P < 0.01, ***P < 0.001 by unpaired two-sided t-test. ns, not significant. b, c Viability and IC50 of 2D and 3D cells after treated with bortezomib or ABT-263 for 72 h. Data are presented as mean ± s.d. (n = 3). d, e Immunoblots of 2D and 3D cells after treated with bortezomib (0.1 μM) for the indicated time periods. Quantification of the protein levels is shown at the bottom