Table 1.

Experimental design.

Group	Treatment
Group 1	Normal control (NC)
Group 2	RA control (RAC)
Group 3	FCA + Diclofenac (D) 25 mg/kg
Group 4	FCA + Methotrexate (M) 50 μg/kg/week
Group 5	FCA + EESI 400 mg/kg
Group 6	FCA + EESI 800 mg/kg

Drugs were administered daily orally from day 8–28.