Table 2.

Effect on paw volume.

Groups	Treatment	Paw volume (ml)
		Day 0	Day 7	Day 14	Day 21	Day 28
I	Normal control	0.14 ± 0.02	0.16 ± 0.02	0.15 ± 0.01	0.12 ± 0.01	0.13 ± 0.01
II	RA control	0.12 ± 0.02	1.03 ± 0.28	0.77 ± 0.03	0.85 ± 0.03	0.82 ± 0.02
III	Diclofenac	0.12 ± 0.02	1.03 ± 0.03	0.87 ± 0.09	0.40 ± 0.03*	0.28 ± 0.02**
IV	Methotrexate	0.17 ± 0.03	1.03 ± 0.09	0.87 ± 0.03	0.42 ± 0.03*	0.23 ± 0.02**
V	SI 400 mg/kg	0.15 ± 0.02	1.07 ± 0.05	0.83 ± 0.03	0.39 ± 0.02*	0.38 ± 0.02*
VI	SI 800 mg/kg	0.16 ± 0.02	0.97 ± 0.05	0.88 ± 0.03	0.38 ± 0.02*	0.20 ± 0.02**

Values expressed as Mean ± SEM, n = 6, *P < 0.05, **P < 0.01 with RA Control, #P < 0.05 with diclofenac, a P < 0.05 with methotrexate.