Table 4.

Effect on In-vivo antioxidant activity.

Groups	Treatment	LPO (nmol/mg of protein)	SOD (U/mg of protein)	CAT (nmol/min/mg of protein)	GPx (nmol/min/mg protein)
I	Normal control	8.23 ± 0.77	14.34 ± 1.08	301.49 ± 45.89	170.62 ± 10.89
II	RA control	13.34 ± 1.2	6.2 ± 0.51	134.96 ± 16.61	90.13 ± 1.37
III	Diclofenac	10.45 ± 1.32*	10.24 ± 0.72*	217.51 ± 40.5	119.22 ± 1.22*
IV	Methotrexate	10.11 ± 1.7*	10.11 ± 0.19*	235.62 ± 35.48*	127.88 ± 5.69**
V	SI 400 mg/kg	10.98 ± 1.01	8.8 ± 0.72	201.87 ± 44.25	114.45 ± 2.98
VI	SI 800 mg/kg	8.93 ± 1.09*	11.5 ± 0.89**	262.24 ± 44.75*	137.36 ± 3.82**

Values expressed as Mean ± SEM, n = 6, *P < 0.05, **P < 0.01 with RA Control, #P < 0.05 with diclofenac, a P < 0.05 with methotrexate.