. 2018 Feb 16;26(5):634–642. doi: 10.1016/j.jsps.2018.02.029

Table 4.

Mean changes and clinical parameters reported by selected studies.

Study (Authors and year)	PD (mm) Mean ± SD		RAL/CAL (mm) Mean ± SD		GML (mm) Mean ± SD		IBD depth (mm)Mean ± SD		IBD fill (%)Mean ± SD
Pradeep et al. (2013)	0%MF + SRP	1.77 ± 0.77	0%MF + SRP	1.33 ± 0.66	N/A		0%MF + SRP	1.19 ± 0.38	0%MF + SRP	3.35 ± 8.36
	0.5%MF + SRP	2.96 ± 0.93	0.5%MF + SRP	2.23 ± 0.73	N/A		0.5%MF + SRP	1.03 ± 0.20	0.5%MF + SRP	21.11 ± 3.81
	1%MF + SRP	4.0 ± 1.05	1%MF + SRP	3.83 ± 0.95	N/A		1%MF + SRP	1.57 ± 0.57	1%MF + SRP	31.89 ± 10.26
	1.5%MF + SRP	3.8 ± 1.03	1.5%MF + SRP	3.6 ± 0.81	N/A		1.5%MF + SRP	1.38 ± 0.69	1.5%MF + SRP	26.8 ± 5.52
Rao et al. (2013)	0%MF + SRP	0.87 ± 0.94	0%MF + SRP	1.47 ± 0.78	N/A		0%MF + SRP	0.22 ± 0.38	0%MF + SRP	3.75 ± 8.06
Rao et al. (2013)	1%MF + SRP	3.17 ± 0.75	1%MF + SRP	3.27 ± 0.79	N/A		1%MF + SRP	1.32 ± 0.4	1%MF + SRP	26.17 ± 0.66
Pradeep et al. (2016)	0%MF + SRP	2.0 ± 1.01	0%MF + SRP	1.43 ± 0.97	N/A		0%MF + SRP	0.23 ± 0.12	0%MF + SRP	4.79 ± 2.3
Pradeep et al. (2016)	1%MF + SRP	3.96 ± 0.66	1%MF + SRP	4.06 ± 0.86	N/A		1%MF + SRP	1.35 ± 0.34	1%MF + SRP	26.17 ± 0.66
Pradeep et al. (2015)	OFD	3.00 ± 0.18	OFD	2.96 ± 0.18	OFD	- 0.06 ± 0.04	OFD	0.49 ± 0.27	OFD	9.14 ± 0.004
	OFD + PRP	4.00 ± 0.18	OFD + PRP	4.03 ± 0.18	OFD + PRP	0.27 ± 0.07	OFD + PRP	2.53 ± 0.30	OFD + PRP	48 ± 0.029
	OFD + 1%MF	3.93 ± 0.25	OFD + 1%MF	3.83 ± 0.25	OFD + 1%MF	0.27 ± 0.05	OFD + 1%MF	2.56 ± 0.28	OFD + 1%MF	48.69 ± 0.026
	OFD + 1%MF + PRF	4.90 ± 0.30	OFD + 1%MF + PRF	4.90 ± 0.30	OFD + 1%MF + PRF	0.33 ± 0.07	OFD + 1%MF + PRF	2.77 ± 0.3	OFD + 1%MF + PRF	52.65 ± 0.031

CAL, clinical attachment level; GML, gingival marginal level; IBD, intrabony defect; MF, metformin gel; OFD, open flap debridement; PD, probing depth; SD, standard deviation; SRP, scaling and root planing.