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Rough IC50 values for inhibition of enzyme-selective substrates metabolites formation by TQ (n = 3, best-fit IC50 values ± SE). All resulting values had r2 value for goodness of fit of at least 0.9.
| Enzyme | IC50 (µM) |
|---|---|
| CYP1A2 | 26.5 ± 2.9 |
| CYP3A4 | 25.2 ± 3.1 |
| CYP2C9 | 0.5 ± 0.4 |
| CYP2D6 | >500 |
