Fig. 1.

Inhalation exposure system composes of six major components. (A) Cigarette smoke generation: multiple type of cigarettes such as combustible and electronic-cigarettes can be used in the apparatus to generate smoking. (B) Nose-only exposure: animals can be placed in mask holders to provide only nose exposure to cigarettes. (C) InExpose pumps: these pumps are designed to generate smoking. (D) InExpose base unit: the base unit is connected to the software to control the exposure parameters such as exposure time and exposure duration. (E) Whole body chamber: whole body animals can be placed in chambers to expose the whole body to cigarettes. (F) Flexiware software: the exposure temperature, patterns of smoking and humidity as well as the exposure time and duration can be modified practically by the software. The image is adopted with permission from SCIREQ Scientific Respiratory Equipment Inc. (http://www.scireq.com/inexpose).