Table IV.
Baseline characteristics
| Fracture group (F) (n = 9)* | Non-fracture group (NF) (n = 38)* | p-value | |
|---|---|---|---|
| Gender, n (%) | |||
| Male | 4 (44) | 20 (53) | 0.7† |
| Female | 5 (56) | 18 (47) | |
| Median age, yrs (IQR) | 66.0 (57.5 to 75.0) | 62.5 (52.8 to 76.5) | 0.5‡ |
| Median body weight, kg (IQR) | 73.0 (63.0 to 76.5) | 76.0 (57.8 to 87.3) | 0.6‡ |
| Radiation schedule, n (%)§ | |||
| Single fraction | 4 (44) | 15 (39) | 1† |
| Multiple fractions | 5 (56) | 23 (61) | |
| Median Karnofsky performance status (IQR) | 80.0 (70.0 to 80.0) | 80.0 (70.0 to 90.0) | 0.6‡ |
| Median time since primary tumour, yrs (IQR) | 3.6 (1.7 to 6.5) | 3.3 (0.8 to 5.5) | 0.8‡ |
| Median time since first metastasis, yrs (IQR) | 3.2 (0.1 to 3.6) | 1.1 (0.1 to 2.8) | 0.5‡ |
| Primary cancer site, n (%) | |||
| Breast | 2 (22) | 11 (29) | 0.3¶ |
| Lung | 2 (22) | 5 (13) | |
| Prostate | 2 (22) | 12 (32) | |
| Kidney | 0 (0) | 4 (11) | |
| Rectum | 0 (0) | 2 (5) | |
| Multiple myeloma | 3 (33) | 2 (5) | |
| Urethra | 0 (0) | 1 (3) | |
| aCUP** | 0 (0) | 1 (3) | |
| Median time to death since inclusion, mths (IQR)†† | 11.0 (4.0 to 13.0) | 8.0 (3.0 to 17.0) | 0.9‡ |
| Institute, n (%) | |||
| 1 | 5 (56) | 11 (29) | 0.3¶ |
| 2 | 3 (33) | 23 (61) | |
| 3 | 1 (11) | 4 (11) | |
| Lesion type, n (%) | |||
| Not visible | 1 (11) | 3 (8) | 0.4¶ |
| Lytic | 1 (11) | 13 (34) | |
| Mixed | 7 (78) | 22 (58) |
*
Fracture group: nine femurs in seven patients. Non-fracture group: 38 femurs in 34 patients. Two patients had one fractured and one non-fractured femur
†
Fisher’s exact test
‡
Mann–Whitney U test
§
Two femurs in the fracture group were not treated with radiotherapy
¶
Chi-squared test
**
Cancer of unknown primary origin
††
Date of death missing for three non-fracture patients
IQR, interquartile range