Table 1.

Partial List of CNS CAMs Processed by Metalloproteinases

Cell Adhesion Molecule	Cell Types for which Expression has been Reported	Metalloproteinase(s) that Mediate Shedding	Reference(s)
ICAM-1	Astrocytes, oligodendrocytes, leukocytes, endothelial cells	ADAM-17	[86–90]
ICAM-5	Glutamatergic neurons of the telencephalon	MMP-2,-3,-7,-9	[37, 75]
NCAM	Neurons, astrocytes, oligodendrocytes, microglia, endothelium	ADAM protease	[91–95]
L1-CAM	Neurons, oligodendrocytes, endothelial cells	ADAM-10, ADAM-17	[96–99]
VCAM	Neurons, astrocytes, microglia, endothelial cells	ADAM-9	[100–104]
N-Cadherin	Astrocytes, oligodendrocytes	ADAM-10, MMP-7	[7, 105–108]
E-Cadherin	Neurons and endothelial cells	MMP-7, ADAM-10, ADAM-15	[109–114]
VE-Cadherin	Neuronal stem cells, astrocytes and endothelial cells	MMP-7	[115]
Nectin-1	Neurons	ADAM-10	[116–118]
Syndecan-1	Neurons and astrocytes [expression upreulated with injury], endothelial cells	MT1-MMP, MMP-7, MMP-9	[119–125]
SIRP-1α	Neurons, astrocytes, microglia, endothelial cells	Unknown metalloproteinase[s]	[126–130]