Table 1.
Animal characteristics and laboratory parameters
| sham + vehicle | sham + dapa | sham + T-1095 | MI + vehicle | MI + dapa | MI + T-1095 | |
|---|---|---|---|---|---|---|
| N | 12 | 7 | 6 | 22 | 13 | 15 |
| BW (g) | 305.3 ± 3.8 | 281.3 ± 3.3* | 248.3 ± 8.1* | 299.9 ± 3.1 | 282.8 ± 5.0*† | 263.5 ± 4.2*† |
| LV W/TL (g/mm) | 14.8 ± 0.1 | 13.4 ± 0.1* | 12.2 ± 0.3* | 15.9 ± 0.2* | 15.0 ± 0.2† | 14.1 ± 0.4† |
| Lung W/TL (g/mm) | 27.4 ± 0.5 | 26.8 ± 0.3 | 24.7 ± 0.4 | 43.7 ± 3.9* | 40.3 ± 4.4* | 54.2 ± 5.0*† |
| UG (mmol/l) | 0.34 ± 0.07 | 316.0 ± 34.3* | 256.2 ± 66.6* | 0.21 ± 0.03 | 235.0 ± 10.3*† | 205.2 ± 21.6*† |
| Fructosamine (μM) | 141.8 ± 3.3 | 126.2 ± 2.4* | 129.2 ± 2.8* | 121.5 ± 3.3* | 122.5 ± 2.0* | 130.8 ± 4.4*† |
| ANP: RPL13a mRNA (AU) | 1.09 ± 0.23 | 1.39 ± 0.44 | 1.52 ± 0.23 | 13.02 ± 2.33* | 7.47 ± 1.15*† | 9.61 ± 1.07* |
BW body weight, SBP systolic blood pressure, LVW left ventricle weight, TL tibia length, Lung W lung weight, BG blood glucose, UG urinary glucose, ANP atrial natriuretic peptide, RPL13a Ribosomal Protein L13a, AU arbitrary units, dapa dapagliflozin
* p < 0.05 vs. sham + vehicle group; † p < 0.05 vs. MI + vehicle group