Table 2.
sham + vehicle | sham + dapa | sham + T-1095 | MI + vehicle | MI + dapa | MI + T-1095 | |
---|---|---|---|---|---|---|
N | 12 | 7 | 6 | 20 | 12 | 14 |
MI size (%) | – | – | – | 44 ± 2 | 38 ± 2 | 40 ± 2 |
FS (%) | 53 ± 1 | 55 ± 3 | 50 ± 3 | 19 ± 1* | 19 ± 1* | 16 ± 1* |
EF (%) | 83 ± 1 | 84 ± 2 | 80 ± 3 | 37 ± 1* | 37 ± 1* | 31 ± 2*†‡ |
LV mass corr. (mg) | 684 ± 26 | 608 ± 35* | 578 ± 41 | 827 ± 36* | 800 ± 41* | 759 ± 39 |
LVIDd (mm) | 6.73 ± 0.08 | 6.62 ± 0.18* | 6.50 ± 0.07* | 9.17 ± 0.15* | 9.21 ± 0.18* | 9.05 ± 0.11* |
LVIDs (mm) | 3.17 ± 0.09 | 3.01 ± 0.25 | 3.25 ± 0.18 | 7.47 ± 0.17* | 7.48 ± 0.20* | 7.64 ± 0.11* |
Volume s (μl) | 63 ± 4 | 52 ± 6 | 56 ± 10 | 359 ± 28* | 371 ± 32* | 402 ± 18* |
Volume d (μl) | 289 ± 15 | 272 ± 19 | 223 ± 13 | 574 ± 25* | 555 ± 31* | 556 ± 19* |
EF ejection fraction, FS fractional shortening, LV mass corr left ventricle mass corrected, LVPW left ventricular posterior wall, LVIDd left ventricle internal diameter in diastole, LVIDs left ventricle internal dimension in systole
* p < 0.05 vs. sham + vehicle group; † p < 0.05 vs. MI + vehicle group; ‡ p < 0.05 vs. MI + dapagliflozin group