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. 2018 Jul 6;11:57. doi: 10.1186/s12920-018-0372-8

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Cumulative percentage of all the phenotype-gene associations from the 230 clinical cases that appeared within the Top-k of the ranked gene list. The phenotype-gene associations that are already present in Orphanet are excluded from the calculation. The candidate methods are GCAS and BiRW _mod