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. 2018 Jul 6;18:75. doi: 10.1186/s12874-018-0534-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Calculation of comparative efficacy of drug D1 vs. D2 obtained from virtual Phase III RCTs. This calculation is repeated for each type of RCT population augmentation (= each relaxed criterion)