Table 1.

Role of Nec-1 in neurodegenerative diseases

S. no.	Neurodegenerative disease	Role of Nec-1	References
1	Alzheimer’s disease	Nec-1 promotes the neural cell death and improves neurobehavior in Al-treated mice model. Nec-1 also ameliorates cognitive dysfunction, significantly reducing the level of Aβ and tau in APP/PS1 mice model.	[106, 107]
2	Parkinson’s disease	Nec-1 enhanced the cell survival in 6-OHDA-treated PC12 cells	[108]
3	Huntington’s disease	Nec-1 increased survival rate in ST14 8plx cells	[100]