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. 2018 Jul 6;13:111. doi: 10.1186/s13023-018-0855-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Localisation and structure of laminin 332 at the dermo-epidermal junction. a Laminin 332, a major component of the lamina densa, is an extracellular matrix protein binding to collagen XVII/BP180, α6β4 integrin, and collagen VII. b Laminin 332 is a heterotrimer composed of α3, β3, and γ2 chains showing a cross-like structure with a large globular domain at the base of the cross