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. 2018 Jul 6;11:397. doi: 10.1186/s13071-018-2984-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — PD-1 deficiency contributed to the expansion of TFR cells in both naïve and immunized mice. Splenocytes were isolated from immunized WT (n = 5) and PD-1^-/- mice (n = 5) at the indicated times after the final immunization, and both the frequency and number of TFR cells were analyzed by FACS. a Representative FACS analysis of CD4⁺ICOS⁺CXCR5⁺Foxp3⁺CD19⁻ cells. b, c Statistical analysis of the frequency and number of TFR cells from ITV-immunized WT and PD-1^-/- mice on days 7, 14 and 21 after the final immunization. Three individual experiments were performed. The data are presented as the mean ± SD. Data were compared with the two-way ANOVA. Abbreviation: n, number of samples