Table 5.
Studies assessing the association between urinary thiocyanate concentration and maternal thyroid status in pregnancy
| Author (year) | Country | N | Gestation | Median UIC (μg/l) | Median UTC (range) (μg/l) | Association of UTC with | |
|---|---|---|---|---|---|---|---|
| Maternal TSH | Maternal FT4 | ||||||
| Pearce, 2010 [6] | Italy | 787a | 1st trimester | 55–60 | 373 (132–6650) | No | Yes (negative)c |
| Wales | 854b | 98–117 | 471 (34–3100) | No | No | ||
| Pearce, 2012 [8] | Greece | 134 | 1st trimester | 120 | 413 (0.6–1635) | Yes (positive)d | No |
| Charatcharoenwitthaya, 2014 [9] | Thailand | 200 | 1 s trimester | 153.5 | 510.5 (68–3525) | Yes (positive) | Yes (negative) |
| Horton, 2015 [10] | USA | 284 | 1st trimester | 235 (mean)e | 1006 (mean)e | No | No |
| This study | England | 308 | 3rd trimester | 88 | 436 (29–3290) | No | No |
FT4 free T4, TSH thyroid stimulating hormone, NK not known, UIC urinary iodine concentration, UTC urinary thiocyanate concentration
aIncludes 261 women with hypothyroidism/hypothyroxinaemia (median UIC 55 μg/l) and 526 euthyroid women (median UIC 50 μg/l)
bIncludes 374 women with hypothyroidism/hypothyroxinaemia (median UIC 98 μg/l) and 480 euthyroid women (median UIC 117 μg/l)
cNegative correlation in the euthyroid cohort on univariate analysis
dPositive association on univariate analysis but no longer associated after adjustments in multivariate analysis
eCreatinine – adjusted (μg/g creatine)