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. 2018 Apr 27;26(7):1771–1782. doi: 10.1016/j.ymthe.2018.04.023

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Schematic Representation of the Experimental Designs for All Presented Studies

Wild-type (WT), GSD III (Agl^−/−), and GSD Ia (L-G6pc^−/−) mice were injected (downward open arrows) with either GYS2-1 or GYS2-2 with different dose levels, dosing regimens, and study durations (takedown denoted with upward filled arrows) as indicated. Age of mice is indicated within horizontal arrows. Results obtained from each experimental protocol are presented in their corresponding figures and supplemental figures as indicated.