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AXT050 binding and biodistribution. A AXT050 binds to αvβ3 with a kon of 1 μM−1s−1, koff of 0.0032 s−1, and KD of 3.2 nM. B-C AXT050 accumulated in MDA-MB-231 tumors and was cleared through the kidney with D a blood circulation half-life of ~11 min.
