Biophysical characterization of non-targeted AXT050-containing PLGA NP. A Hydrodynamic diameter (NTA) of non-modified PLGA NPs formulated with different conditions and a representative TEM image of PLGA NPs from “60 A” condition, B TEM image of anisotropic PLGA NPs (“60 A” PLGA NPs stretched 2-fold), C Stability of PLGA-PEG NPs over 3 days in different media by DLS (closed circle/solid line: size, open circle/dashed line: polydispersity index), and D Biodistribution of non-targeted NPs. NTA: mean ± SD (n > 200 particles), TEM: scale bar = 1 μm.