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Fabrication of PLGA-PEG-AXT050 nanoparticles. (A) PLGA-PEG-NHS polymer is reacted with AXT050 to form PLGA-PEG-AXT050 conjugates. (B) Nanoparticles are formed by nanoprecipitation utilizing PLGA-PEG-AXT050 and PLGA-mPEG at varied mass ratios including 100%:0%, 50%:50%, 10%:90%, and 0%:100% PLGA-PEG-AXT050: PLGA-mPEG polymer.
