Table.
Baseline Characteristics of the Participants by Randomized Assignment (N = 102)a
| 2.5 mg/d of Dutasteride (n = 48) | Placebo (n = 54) | |||||||
|---|---|---|---|---|---|---|---|---|
| Dosage of Testosterone Enanthate, mg/wk | ||||||||
| 50 (n = 13) | 125 (n = 9) | 300 (n = 12) | 600 (n = 14) | 50 (n = 15) | 125 (n = 12) | 300 (n = 12) | 600 (n = 15) | |
| Demographics | ||||||||
| Age, y | 41 (9) | 40 (7) | 35(8) | 35 (9) | 39 (9) | 34 (8) | 37 (10) | 40 (8) |
| Height, cm | 174 (6) | 176 (7) | 175 (6) | 178 (7) | 177 (4) | 178 (9) | 177 (8) | 178 (6) |
| Weight, kg | 80 (10) | 84 (11) | 77 (14) | 86 (16) | 82 (13) | 84 (14) | 82 (12) | 82 (12) |
| Measures of body composition and muscle performance | ||||||||
| Fat-free mass, kg | 62 (7) | 63 (10) | 59 (9) | 66 (9) | 62 (7) | 64 (8) | 61 (7) | 63 (9) |
| Lean body mass, kg | 60 (7) | 60 (9) | 57 (9) | 63 (9) | 59 (7) | 61 (8) | 59 (7) | 60 (9) |
| Fat mass, kg | 16 (5) | 19 (7) | 16 (6) | 18 (10) | 19 (9) | 18 (8) | 19 (9) | 18 (6) |
| Leg-press strength, N | 2787 (482) | 3005 (834) | 2830 (648) | 3006 (731) | 2771 (499) | 2964 (498) | 2865 (543) | 2995 (789) |
| Leg-peak power, W | 1713 (340) | 1904 (458) | 1858 (516) | 2069 (592) | 1902 (448) | 2084 (520) | 2007 (488) | 1895 (441) |
| Chest-press strength, N | 784 (163) | 759 (228) | 713 (210) | 817 (272) | 711 (249) | 763 (142) | 734 (205) | 735 (249) |
| Baseline blood levels | ||||||||
| Total testosterone, ng/dL | 770 (275) | 842 (399) | 590 (198) | 676 (221) | 697 (320) | 701 (268) | 667 (175) | 776 (255) |
| Free testosterone, ng/dL | 16.8 (11.4) | 16.0 (9.0) | 11.9 (4.5) | 12.5 (4.6) | 12.1 (4.8) | 12.7 (5.6) | 12.8 (4.5) | 13.2 (5.1) |
| Total 5α-dihydrotestosterone, ng/dL | 50 (22) | 51 (13) | 49 (15) | 54 (23) | 59 (27) | 57 (22) | 54 (19) | 62 (27) |
| Free 5α-dihydrotestosterone, pg/mL | 4.7 (1.9) | 4.6 (2.1) | 4.7 (1.8) | 4.5 (2.6) | 4.5 (1.3) | 4.6 (1.3) | 5.4 (2.9) | 4.7 (1.5) |
| Luteinizing hormone, U/L | 3.2 (1.4) | 4.2 (3.8) | 3.5 (3.1) | 2.7 (1.1) | 3.8 (1.5) | 3.6 (1.2) | 3.4 (1.3) | 3.5 (1.1) |
| Prostate volume, cm3 | 20.3 (4.0) | 23.7 (3.2) | 21.4 (1.9) | 22.3 (3.4) | 22.2 (4.8) | 20.9 (3.7) | 23.7 (6.7) | 23.4 (3.2) |
| Prostate-specific antigen, ng/mL | 0.59 (0.24) | 0.60 (0.33) | 0.81 (0.20) | 0.75 (0.38) | 0.85 (0.40) | 0.42 (0.09) | 0.60 (0.27) | 0.77 (0.45) |
| Osteocalcin, ng/mL | 18.9 (5.0) | 18.3(4.9) | 20.6 (5.8) | 22.7 (6.7) | 26.5 (8.7) | 24.2 (7.5) | 19.2 (8.7) | 20.5(7.4) |
| N-telopeptide, nmol bone collagen equivalent/L | 11.1 (3.1) | 13.8 (5.0) | 13.2 (2.8) | 13.1 (2.5) | 14.5 (5.6) | 14.9 (7.5) | 12.7 (3.2) | 12.1 (5.2) |
| Hemoglobin, g/dL | 14.8 (1.0) | 15.0 (0.5) | 14.2 (1.4) | 15.0 (0.8) | 14.8 (0.7) | 14.2 (1.0) | 15.2 (0.9) | 14.9 (1.0) |
| Hematocrit, % | 43.4 (3.0) | 43.4 (1.7) | 41.6 (4.1) | 43.7 (2.0) | 43.3 (1.7) | 41.4 (2.4) | 44.0 (2.4) | 43.6 (3.0) |
| Cholesterol, mg/dL | ||||||||
| Total | 192 (24) | 176 (30) | 176 (37) | 196 (42) | 183 (28) | 177 (40) | 160 (32) | 188 (26) |
| Low-density lipoprotein | 121 (19) | 112 (30) | 108 (34) | 120 (37) | 105 (27) | 104 (36) | 93 (23) | 112 (28) |
| High-density lipoprotein | 51 (10) | 45 (10) | 47 (13) | 56 (18) | 55 (17) | 55 (14) | 51 (20) | 55 (15) |
| Triglycerides, mg/dL | 100 (49) | 98 (32) | 105 (56) | 98 (44) | 115 (58) | 85 (41) | 102 (58) | 102 (37) |
| Sexual function | ||||||||
| International Index of Erectile Function | ||||||||
| Total | 57 (10) | 53 (13) | 55 (10) | 57 (17) | 58 (12) | 55 (12) | 54 (9) | 58 (8) |
| Sexual desire | 7.8 (1.5) | 7.7 (1.5) | 7.5 (1.9) | 7.7 (2.1) | 8.1 (2.0) | 7.3 (1.3) | 7.8 (1.5) | 7.8 (1.3) |
| Erectile function | 23.2 (6.0) | 21.6 (5.7) | 23.5 (5.8) | 23.8 (8.0) | 24.1 (5.7) | 24.4 (6.1) | 23.1 (5.3) | 26.0 (4.7) |
| Orgasmic function | 8.7 (1.4) | 7.9 (2.5) | 8.6 (1.3) | 8.2 (3.0) | 8.3 (1.6) | 8.2 (1.7) | 7.4 (2.2) | 8.3 (1.6) |
| Intercourse satisfaction | 9.5 (3.6) | 8.8 (3.5) | 8.5 (4.1) | 10.2 (3.6) | 10.2 (3.3) | 8.9 (3.2) | 8.8 (3.2) | 9.4 (2.8) |
| Overall satisfaction | 7.6 (1.2) | 6.7 (2.5) | 6.8 (1.3) | 6.9 (2.9) | 7.6 (2.0) | 6.4 (2.0) | 6.3 (2.1) | 6.7 (2.4) |
| Male Sexual Health Questionnaire | ||||||||
| Total | 64 (8) | 64 (13) | 63 (7) | 63 (16) | 65 (9) | 65 (7) | 64 (8) | 66 (5) |
| Ejaculation | 30 (3) | 29 (5) | 31 (2) | 29 (7) | 30 (4) | 30 (2) | 30 (3) | 30 (2) |
| Erection | 12 (3) | 12 (2) | 13 (2) | 12 (3) | 13 (2) | 13 (2) | 12 (2) | 13 (2) |
| Satisfaction | 22 (4) | 23 (6) | 20 (6) | 22 (7) | 23 (5) | 23 (5) | 21 (5) | 22 (4) |
| Sebum forehead score | 3.6 (1.2) | 3.6 (0.9) | 4.2 (1.1) | 4.2 (0.9) | 3.7 (1.2) | 4.2 (0.9) | 3.8 (1.5) | 4.4 (0.7) |
SI conversion factors: To convert free 5α-dihydrotestosterone to pmol/L, multiply by 3.44; hemoglobin to g/L, multiply by 10; high-density, low-density, and total cholesterol to mmol/L, multiply by 0.0259; total 5α-dihydrotestosterone to nmol/L, multiply by 0.0344; total or free testosterone to nmol/L, multiply by 0.0347; triglycerides to mmol/L, multiply by 0.113.
a
Values are expressed as mean (SD).