Fig. 1.

(A) Representative TEM image of rNG-DFO (scale: 500 nm). (B) Under oxidative stimuli, thioketals in the nanogels cleave and acetone is released as nanogels degrade into water-soluble polymeric fragments. Shown below are degradation profiles as monitored by DLS for rNG-DFO incubated with 100 μM H₂O₂ at 0 h (black line), 12 h (red line) and 24 h (blue line). (C) Representative UV-Vis absorption spectrum of DFO, rNG and rNG-DFO in the absence and presence of iron(III) reveal that only DFO and rNG-DFO display the characteristic absorbance peak at 430 nm for the DFO:iron(III) complex.