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. Author manuscript; available in PMC: 2018 Aug 2.
Published in final edited form as: Leukemia. 2018 Feb 2;32(7):1575–1586. doi: 10.1038/s41375-018-0016-1

Figure 5. Adult SIPs are serially transplantable, and converted in vivo to HSC with multilineage differentiation capability in primary and secondary recipients.

Figure 5

(a) Percentage of total human hematopoietic (myeloid and lymphoid) engraftment at 2 months post-transplant in animals transplanted with SIPs (n=10); each mark represents levels of engraftment within one animal. (b) Overall percentage of engraftment within the different hematopoietic lineages. (c) HSC generated in primary recipients are serially transplantable. Analysis of human hematopoietic engraftment in blood and marrow in secondary recipients (n=8), as determined by the percentage of human myeloid and lymphoid cells at 2 months post-transplant, is shown.