Table 3.
Mean Compartmental BMD and Bone Microarchitecture Parameters (95% CI) at Distal Radius According to Weight Change Category (N=1638)
| Weight Loss ≥10%(n=243) | Weight Loss5% to <10%(n=382) | Stable Weight(Loss or Gain <5%)(n=872) | Weight Gain ≥5%(n=141) | P-value | |
|---|---|---|---|---|---|
| Base model* | |||||
| FEA estimated failure load, N | 4672 (4507, 4837) | 4739 (4607, 4870) | 4944 (4857, 5031) | 4884 (4668, 5100) | 0.009 |
| FEA proximal cortical load fraction, % | 75.5 (74.5, 76.5) | 76.2 (75.4, 77.0) | 76.7 (76.1, 77.2) | 77.7 (76.4, 79.1) | 0.05 |
| Integral BMD, mg/cm3 | 265.5 (257.9, 273.0) | 267.9 (261.9, 274.0) | 278.0 (274.0, 282.0) | 280.5 (270.6, 290.4) | 0.003 |
| Total area, mm2 | 398.7 (390.5, 407.0) | 399.5 (392.9, 406.0) | 396.5 (392.1, 400.8) | 388.6 (377.7, 399.4) | 0.38 |
| Trabecular BMD, mg/cm3 | 167.6 (162.7, 172.6) | 167.3 (163.4, 171.3) | 171.9 (169.3, 174.5) | 170.4 (163.9, 176.9) | 0.20 |
| Trabecular bone volume fraction, mm3 | 0.233 (0.225, 0.240) | 0.232 (0.227, 0.238) | 0.240 (0.236, 0.244) | 0.238 (0.228, 0.247) | 0.13 |
| Trabecular number, mm 1 | 1.38 (1.35, 1.41) | 1.39 (1.37, 1.41) | 1.41 (1.40, 1.43) | 1.41 (1.37, 1.44) | 0.09 |
| Trabecular thickness, mm | 0.248 (0.246, 0.250) | 0.246 (0.244, 0.248) | 0.247 (0.246, 0.248) | 0.248 (0.245, 0.251) | 0.54 |
| Cortical BMD, mg/cm3 | 782.4 (774.1, 790.8) | 789.3 (782.7, 796.0) | 798.5 (794.1, 802.9) | 806.0 (795.1, 817.0) | <0.001 |
| Cortical thickness, mm | 0.92 (0.89, 0.95) | 0.93 (0.91, 0.96) | 0.97 (0.95, 0.98) | 0.98 (0.94, 1.01) | 0.003 |
| Cortical porosity, % | 1.66 (1.56, 1.77) | 1.55 (1.47, 1.63) | 1.58 (1.53, 1.64) | 1.62 (1.48, 1.75) | 0.36 |
| Multivariable model† | |||||
| FEA estimated failure load, N | 4632 (4468, 4796) | 4721 (4592, 4851) | 4955 (4869, 5041) | 4935 (4722, 5148) | <0.001 |
| FEA proximal cortical load fraction, % | 75.6 (74.6, 76.7) | 76.3 (75.5, 77.1) | 76.6 (76.1, 77.2) | 77.7 (76.4, 79.0) | 0.08 |
| Integral BMD, mg/cm3 | 264.3 (256.9, 271.8) | 268.2 (262.4, 274.1) | 278.2 (274.3, 282.1) | 280.5 (270.8, 290.1) | 0.001 |
| Total area, mm2 | 397.5 (390.1, 405.0) | 397.3 (391.4, 403.2) | 397.0 (393.1, 400.9) | 393.2 (383.5, 402.9) | 0.90 |
| Trabecular BMD, mg/cm3 | 166.3 (161.4, 171.3) | 167.4 (163.5, 171.3) | 172.2 (169.6, 174.8) | 170.8 (164.4, 177.3) | 0.09 |
| Trabecular bone volume fraction, mm3 | 0.231 (0.224, 0.238) | 0.232 (0.227, 0.238) | 0.240 (0.236, 0.244) | 0.239 (0.229, 0.248) | 0.05 |
| Trabecular number, mm 1 | 1.37 (1.34, 1.40) | 1.39 (1.37, 1.41) | 1.42 (1.40, 1.43) | 1.41 (1.38, 1.45) | 0.007 |
| Trabecular thickness, mm | 0.248 (0.246, 0.250) | 0.246 (0.244, 0.248) | 0.247 (0.246, 0.248) | 0.247 (0.244, 0.250) | 0.59 |
| Cortical BMD, mg/cm3 | 783.3 (775.0, 791.6) | 789.7 (783.1, 796.3) | 798.3 (793.9, 802.6) | 805.4 (794.6, 816.2) | 0.002 |
| Cortical thickness, mm | 0.92 (0.89, 0.95) | 0.93 (0.91, 0.96) | 0.97 (0.95, 0.98) | 0.98 (0.94, 1.01) | 0.001 |
| Cortical porosity, % | 1.67 (1.56, 1.77) | 1.55 (1.47, 1.63) | 1.58 (1.53, 1.64) | 1.61 (1.47, 1.74) | 0.36 |
*
adjusted for age, race, and site
†
adjusted for age, race, site, health status, body mass index, limb length and physical activity