Table 4.
Mean Compartmental BMD and Bone Microarchitecture Parameters (95% CI) at Diaphyseal Tibia According to Weight Change Category (N=1442)
| Weight Loss ≥10%(n=207) | Weight Loss 5% to <10%(n=345) | Stable Weight(Loss or Gain <5%)(n=772) | Weight Gain ≥ 5%(n=118) | P-value | |
|---|---|---|---|---|---|
| Base model* | |||||
| FEA estimated failure | 19900 | 20085 | 20105 | 19799 | 0.54 |
| load, N | (19544, 20257) | (19809, 20361) | (19921, 20290) | (19326, 20271) | |
| Integral BMD, mg/cm3 | 718.6 (708.2, 729.1) | 732.0 (723.9, 740.1) | 732.3 (726.9, 737.7) | 736.5 (722.7, 750.3) | 0.10 |
| Total area, mm2 | 444.5 (437.5, 451.6) | 439.3 (433.8, 444.7) | 438.9 (435.2, 442.5) | 431.0 (421.6, 440.4) | 0.16 |
| Cortical BMD, mg/cm3 | 996.3 (991.6, 1001.0) | 998.0 (994.4, 1001.6) | 995.3 (992.9, 997.7) | 997.1 (990.9, 1003.3) | 0.66 |
| Cortical thickness, mm | 6.01 (5.89, 6.13) | 6.15 (6.06, 6.24) | 6.17 (6.11, 6.23) | 6.13 (5.98, 6.28) | 0.12 |
| Cortical porosity, % | 2.26 (2.10, 2.42) | 2.11 (1.99, 2.24) | 2.11 (2.03, 2.19) | 1.87 (1.66, 2.08) | 0.04 |
| Multivariable model† | |||||
| FEA estimated failure load, N | 19696(19364, 20029) | 19971(19717, 20226) | 20175(20004, 20346) | 20071(19634, 20507) | 0.08 |
| Integral BMD, mg/cm3 | 722.0 (711.7, 732.4) | 731.9 (724.0, 739.9) | 731.6 (726.3, 737.0) | 735.0 (721.4, 748.6) | 0.36 |
| Total area, mm2 | 438.5 (432.2, 444.8) | 437.0 (432.2, 441.9) | 440.6 (437.4, 443.9) | 437.2 (429.0, 445.5) | 0.62 |
| Cortical BMD, mg/cm3 | 1000.1 (995.6, 1004.6) | 998.7 (995.2, 1002.1) | 994.3 (992.0, 996.6) | 994.6 (988.6, 1000.5) | 0.06 |
| Cortical thickness, mm | 5.99 (5.87, 6.10) | 6.13 (6.04, 6.21) | 6.18 (6.12, 6.24) | 6.17 (6.02, 6.32) | 0.03 |
| Cortical porosity, % | 2.23 (2.06, 2.39) | 2.12 (1.99, 2.24) | 2.12 (2.04, 2.20) | 1.88 (1.67, 2.10) | 0.09 |
*
adjusted for age, race, and site
†
adjusted for age, race, site, health status, body mass index, limb length and physical activity