Table 3.
Neuropsychological and neuroimaging factor effects on recurrence
| Neuropsychological Assessments | Recurrent | Non-recurrent | Wald X2 | p value |
|---|---|---|---|---|
| MMSE | N=135 28.1 (2.0) |
N=102 28.2 (2.4) |
1.60 | 0.2061 |
| Episodic Memory | N=113 −0.026 (0.798) |
N = 77 0.006 (0.686) |
1.89 | 0.1697 |
| Executive Function | N=110 −0.090 (0.943) |
N = 76 −0.055 (0.850) |
1.86 | 0.1726 |
| Verbal Fluency | N=112 −0.047 (0.851) |
N=77 −0.103 (0.874) |
0.01 | 0.9558 |
| Working Memory | N=104 −0.062 (0.829) |
N=74 −0.002 (0.758) |
0.52 | 0.4688 |
| Neuroimaging Measures | ||||
| White Matter Hyperintensity Volume | N=59 6.21 (8.93) |
N=57 5.83 (8.96) |
0.09 | 0.7613 |
| Hippocampus, left | N=47 2.98 (0.54) |
N=33 2.94 (0.37) |
0.75 | 0.3867 |
| Hippocampus, right | N=47 3.01 (0.47) |
N=33 3.11 (0.34) |
1.54 | 0.2151 |
| Lateral Ventricles | N=59 36.28 (21.33) |
N=57 39.59 (26.21) |
0.50 | 0.4795 |
| Total Cerebral Gray Matter Volume | N=59 591.0 (87.5) |
N=57 573.2 (82.6) |
3.76 | 0.0525 |
| Total Cerebral Volume | N=59 1148.2 (132.9) |
N=57 1163.1 (139.9) |
0.15 | 0.6965 |
Neuropsychological test models examine z-transformed cognitive domain scores, controlling for age, sex, and education. Neuroimaging measures are presented in milliliters and models control for age, sex, and total cerebral volume, except for models focusing solely on total cerebral volume that control only for age and sex. Sample size included for each model due to missing data. MMSE = Mini-mental state exam.