Table 3.
Univariate and multivariate analysis of independent risk factors associated with late recurrence.
| Variable | Early recurrence (<3 yr) (n = 71) | Late recurrence (≥3 yr) (n = 27) | Univariate analysis (P value) | Multivariate analysis (OR, 95% CI, P value) |
|---|---|---|---|---|
| Age (yr) | 0.382 | |||
| <70 | 56 (78.9%) | 24 (88.9%) | ||
| ≥70 | 15 (21.1%) | 3 (11.1%) | 0.726 (0.174–3.024) 0.660 | |
| Gender | 0.473 | |||
| Male | 39 (54.9%) | 17 (63.0%) | 0.996 (0.361–2.747) 0.993 | |
| Female | 32 (45.1%) | 10 (37.0%) | ||
| Tumor location | 1.000 | |||
| Right colon | 18 (25.3%) | 7 (25.9%) | ||
| Left colon | 12 (16.9%) | 4 (14.8%) | ||
| Rectum | 41 (57.7%) | 16 (59.3%) | ||
| Tumor size | 0.965 | |||
| <5 cm | 24 (33.8%) | 9 (33.3%) | ||
| ≥5 cm | 47 (66.2%) | 18 (66.7%) | ||
| Gross type | 0.280 | |||
| Fungating | 30 (42.3%) | 14 (51.9%) | ||
| Infiltrative | 36 (50.7%) | 10 (37.0%) | ||
| Unknown | 5 (7.0%) | 3 (11.1%) | ||
| Cell type | 0.614 | |||
| Nonmucinous | 68 (95.8%) | 25 (92.6%) | ||
| Mucinous | 3 (4.2%) | 2 (7.4%) | ||
| Differentiation | 0.818 | |||
| WD | 3 (4.2%) | 1 (3.7%) | ||
| MD | 53 (74.6%) | 22 (81.5%) | ||
| PD | 15 (21.1%) | 4 (14.8%) | ||
| Lymphatic invasion | 0.012 | |||
| Absent | 10 (14.1%) | 10 (37.0%) | ||
| Present | 61 (85.9%) | 17 (63.0%) | 0.309 (0.103–0.924) 0.036 | |
| Vascular invasion | 1.000 | |||
| Absent | 71 (100%) | 27 (100%) | ||
| Present | 0 (0%) | 0 (0%) | ||
| T category | 0.193 | |||
| T1 | 0 (0%) | 0 (0%) | ||
| T2 | 1 (1.4%) | 2 (7.4%) | ||
| T3 | 67 (94.4%) | 25 (92.6%) | ||
| T4 | 3 (4.2%) | 0 (0%) | ||
| N category | 0.102 | |||
| N0 | 12 (16.9%) | 10 (37.0%) | ||
| N1 | 21 (29.6%) | 6 (22.3%) | ||
| N2 | 38 (53.5%) | 11 (40.7%) | ||
| Stage | 0.051 | |||
| I | 0 (0%) | 1 (3.7%) | ||
| II | 13 (18.3%) | 9 (33.3%) | ||
| III | 58 (81.7%) | 17 (63.0%) | 1.315 (0.256–6.753) 0.743 | |
| COX-2 expression | 0.001 | |||
| Negative | 45 (63.4%) | 7 (25.9%) | ||
| Positive | 26 (36.6%) | 20 (74.1%) | 4.656 (1.696–12.779) 0.003 |