Extended Data Figure 5. Sequence conservation of T. thermophilus RodA.

a, Surface and ribbon representation of RodA (top and bottom panels, respectively). Analysis was performed using Consurf, colored in a scale from teal (poorly conserved) to magenta (highly conserved). A bound lipid modelled as monolien is shown in yellow sticks. The dashed lines represent disordered residues 189 – 227 and 237 – 251 in extracellular loop 4. b, The bound lipid (shown as spheres) is surrounded by many aliphatic amino acids (shown as sticks). c, Extracytoplasmic view of the water-filled central cavity and its proximity to the bound lipid molecule.