Table 3.

Study design for the IP galidesivir efficacy experiment 2.

No./Group	Compound	Day 0 Loading Dose, BID (mg/kg/day)	Dose (mg/kg/day)	Treatment Regimena	Observations & Testing
10	Galidesivir	400	100	BID, 6 days	Observed for weight loss and mortality through day 21
10	Galidesivir	240	60	BID, 6 days
10	Galidesivir		120	BID, 7 days
10	Galidesivir	200	100	QD, 6 days
10	Placebo		0.1 ml LRS	BID, 7 days
10	Ribavirin		100	BID, 7 days
4	Galidesivir	400	100	BID, 1 day	Sacrificed for day 2 viral titers
4	Galidesivir	240	60	BID, 1 day
4	Galidesivir		120	BID, 2 days
4	Galidesivir	200	100	QD, 1 day
4	Placebo		0.1 ml LRS	BID, 2 days
4	Ribavirin		100	BID, 2 days
3	Normal controls for weight change and viral titers (sacrificed on day 21)

^aAll treatments initiated 30 min pre-infection.