Table 4.
Association of HLA-A*02:01 and C*03:04~B*40:01 with Multiple Sclerosis in the presence and absence of DRB1*15:01
| Locus | Haplotype | Controls (N) | Patients (N) | OR | 95% CI Lower | 95%CI Upper | p-value | Significance 1 |
|---|---|---|---|---|---|---|---|---|
| A~C~B | 02:01~03:04~40:01 | 26 | 4 | 0.15 | 0.04 | 0.45 | 6.51E−05 | * |
| A~C~B | 02:01~XXXX~XXXX | 197 | 160 | 0.79 | 0.62 | 1.01 | 4.78E−02 | * |
| A~C~B | YYYY~03:04~40:01 | 24 | 10 | 0.42 | 0.18 | 0.92 | 1.82E−02 | * |
| C~B~DRB1 | 03:04~40:01~WWWW | 47 | 14 | 0.29 | 0.15 | 0.55 | 2.45E−05 | * |
| C~B~DRB1 | ZZZZ~ZZZZ~15:01 | 85 | 253 | 3.95 | 3.00 | 5.23 | 1.24E−25 | * |
| A~DRB1 | 02:01~15:01 | 21 | 56 | 2.85 | 1.68 | 5.01 | 2.885E−05 | * |
| A~DRB1 | 02:01~UUUU | 202 | 108 | 0.48 | 0.37 | 0.62 | 1.13E−08 | * |
| A~DRB1 | VVVV~15:01 | 65 | 197 | 3.76 | 2.77 | 5.15 | 1.09E−19 | * |
UUUU: Any DRB1 allele other than DRB1*15:01
VVVV: Any HLA-A allele other than A*02:01
WWWW: Any DRB1 allele (no C*03:04~B*40:01~DRB1*15:01 haplotypes were observed)
XXXX~XXXX: Any C~B haplotype other than C*03:04~B*04:01
YYYY: Any HLA-A allele other than A*02:01
ZZZZ~ZZZZ: Any C~B haplotype (no C*03:04~B*40:01~DRB1*15:01 haplotypes were observed)
OR: Odds Ratio
CI: Confidence Interval
For each locus, the evaluation of significance was informed by the significance of locus-level heterogeneity as shown in Table 1. P-values were not corrected for loci that displayed significant locus-level heterogeneity. Significant p-values are indicated with asterisks.