. Author manuscript; available in PMC: 2019 Apr 18.

Published in final edited form as: Genes Immun. 2018 Jan 8;20(4):308–326. doi: 10.1038/s41435-017-0006-8

Table 5.

Association of Specific A~C~B~DRB1*15:01~DQB1~DPB1 haplotypes with Multiple Sclerosis

Locus	Haplotype ¹	Controls (N)	Patients (N)	OR	95% CI Lower	95% CI Upper	p-value	Significance ²
A~C~B~DRB1~DQB1~DPB1	02:01~ $07:02$ ~07:02~15:01~06:02~04:01	10	16	1.65	0.7	4.09	2.14E−01	NS
A~C~B~DRB1~DQB1~DPB1	$03:01$ ~ $07:02$ ~07:02~15:01~06:02~04:01	20	53	2.83	1.64	5.04	5.22E−05	*
A~C~B~DRB1~DQB1~DPB1	24:02~ $07:02$ ~07:02~15:01~06:02~04:01	3	13	4.48	1.22	24.6	1.06E−02	*

OR: Odds Ratio

CI: Confidence Interval

HLA-A alleles encoding the A3/A11 KIR ligand, HLA-C alleles encoding the C1 KIR ligand (none shown) and HLA-B alleles encoding the Bw4 KIR ligand are highlighted in grey.

For each locus, the evaluation of significance was informed by the significance of locus-level heterogeneity as shown in Table 1. P-values were not corrected for loci that displayed significant locus-level heterogeneity. Significant p-values are indicated with asterisks. NS: Not Significant.