Table 6.
Association of DRB1~DQB1 genotypes in the presence and absence of HLA-A*02:01 and C~B genotypes in the presence and absence of DRB1*15:01 with Multiple Sclerosis
| Locus | Genotype | Controls (N) | Cases (N) | OR | 95% CI Lower | 95% CI Upper | p-value | Significance 1 |
|---|---|---|---|---|---|---|---|---|
| C~B~DRB1 | 03:04~ 40:01~UUUU+VVVV~VVVV~DRB1*15:01 | 6 | 8 | 1.37 | 0.41 | 4.83 | 5.68E−01 | NS |
| C~B~DRB1 | WWWW~WWWW~UUUU+VVVV~VVVV~DRB1*15:01 | 75 | 215 | 5.06 | 3.65 | 7.04 | 3.21E−13 | * |
| A~DRB1~DQB1 | 02:01~15:01~06:02+02:01~YYYY~YYYY | 5 | 9 | 1.86 | 0.55 | 7.12 | 2.63E−01 | NS |
| A~DRB1~DQB1 | 02:01~15:01~06:02+XXXX~YYYY~YYYY | 17 | 36 | 2.28 | 1.22 | 4.40 | 5.45E−03 | * |
| A~DRB1~DQB1 | 02:01~YYYY~YYYY+02:01~YYYY~YYYY | 16 | 7 | 0.44 | 0.15 | 1.14 | 6.42E−02 | NS |
| A~DRB1~DQB1 | 02:01~YYYY~YYYY+XXXX~15:01~06:02 | 14 | 26 | 1.96 | 0.97 | 4.12 | 4.39E−02 | * |
| A~DRB1~DQB1 | 02:01~YYYY~YYYY+XXXX~YYYY~YYYY | 147 | 55 | 0.29 | 0.20 | 0.41 | 3.70E−13 | * |
| A~DRB1~DQB1 | XXXX~15:01~06:02+XXXX~15:01~06:02 | 2 | 22 | 11.82 | 2.87 | 104.21 | 2.70E−05 | * |
| A~DRB1~DQB1 | XXXX~15:01~06:02+XXXX~YYYY~YYYY | 35 | 111 | 4.07 | 2.67 | 6.32 | 1.50E−12 | * |
OR: Odds Ratio
CI: Confidence Interval
UUUU: Any DRB1 allele (no C*03:04~B*40:01~DRB1*15:01 haplotypes were observed)
VVVV~VVVV: Any C~B haplotype (no C*03:04~B*40:01~DRB1*15:01 haplotypes were observed)
WWWW~WWWW: Any non-C*03:04~B*40:01 haplotype.
XXXX: Any non-A*02:01 allele
YYYY~YYYY: Any non-DRB1*15:01~DQB1*06:02 haplotype.
For each locus, the evaluation of significance was informed by the significance of locus-level heterogeneity. The p-value of locus-level heterogeneity for C~B~DRB1 genotype evaluations is 7.07E−25, and that of locus-level heterogeneity for A~DRB1~DQB1 genotype evaluations is 3.50E−23. P-values were not corrected for loci that displayed significant locus-level heterogeneity. Significant p-values are indicated with asterisks. NS: Not Significant.