Table 9.
Association of HLA-A*02:01 and Bw4 with Multiple Sclerosis
| A. Locus Level Heterogeneity among Tests of Association between HLA-A and Bw4/Bw6 Related Polymorphisms in MS Patients and Controls | ||||
|---|---|---|---|---|
| Locus | χ2 | d.f. | p-value | Significance 1 |
| HLA-A~Bw4/Bw6 | 46.0751 | 24 | 4.34E−03 | * |
| HLA-A~HLA-B Position 80 | 43.2836 | 27 | 2.45E−02 | * |
| B. Association of HLA-A*02:01 and Bw4/Bw6-Related Polymorphism in MS Patients and Controls | ||||||||
|---|---|---|---|---|---|---|---|---|
| Locus | Haplotype | Controls (N) | Cases (N) | OR | 95% CI Lower | 95% CI Upper | p-value | Significance 2 |
| A~Bw4/Bw6 | A*02:01~Bw4 | 123 | 79 | 0.62 | 0.45 | 0.85 | 1.69E−03 | * |
| A~Bw4/Bw6 | A*02:01~Bw6 | 100 | 85 | 0.85 | 0.62 | 1.17 | 3.11E−01 | NS |
| A~HLA-B Position 80 | A*02:01~80I | 45 | 34 | 0.76 | 0.47 | 1.23 | 2.42E−01 | NS |
| A~HLA-B Position 80 | A*02:01~80T | 83 | 45 | 0.53 | 0.35 | 0.78 | 7.55E−04 | * |
Bw4: HLA-B alleles encoding either Threonine at codon 80 (80T) or Isoleucine at codon 80 (80I).
Bw6: HLA-B alleles encoding Asparagine at codon 80 (80N).
d.f.: Degrees of Freedom.
After correcting for two comparisons, significance was evaluated at the 2.5E−02 level. Significant p-values are indicated with asterisks.
For each locus, the evaluation of significance was informed by the significance of locus-level heterogeneity as shown in Table 9A. P-values were not corrected for loci that displayed significant locus-level heterogeneity. P-values for loci that did not display significant locus-level heterogeneity were corrected for the number of analyzed categories.
The complete set of HLA-A~Bw4/Bw6 and A~HLA-B Position 80 comparisons is included in Supplementary Table S5.