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. 2018 Jun;10(Suppl 14):S1645–S1651. doi: 10.21037/jtd.2018.04.68

Table 1. Clinical applications of detection of different cancer-derived molecules or cells in liquid biopsy.

Cancer-derived molecules/cells Clinical applications Reference
Circulating tumor cells (CTCs) Cancer monitoring by quantification of CTC (7,8)
Tumor-derived cell-free DNA Screening of gastric and colorectal cancers by detection of methylated cell-free DNA in serum (9,10)
Screening of EBV-associated cancers (11-13)
Detection of actionable mutations in tumor-derived cell-free DNA for treatment selection (14-22)
Tracking progression and clonal evolution of cancers (23-26)
Tumor-derived cell-free miRNA Plasma or serum miRNA for detection of cancers (27,28)
Extracellular vesicles Detection of tumor-derived extracellular vesicles by surface markers in serum of colorectal cancer patients (29)