Table 1. Univariate Cox regression analysis with survival.
| Characteristicsa | Transplanted groupb (N=45) | Hazard ratio for death (95% CI)c | P value |
|---|---|---|---|
| Biomarkers | |||
| M30 level, U/L | |||
| At 1 h | 59.1±20.4 | 1.349 (1.039–1.752) | 0.025 |
| At 4 h | 88.2±82.9 | 1.093 (1.022–1.169) | 0.009 |
| ∆M30 | 29.1±74.9 | 1.094 (1.013–1.181) | 0.022 |
| M65 level, U/L | |||
| At 1 h | 3,199±2,602 | 1.000 (0.998–1.003) | 0.729 |
| At 4 h | 7,591±6,068 | 1.001 (1.000–1.002) | 0.200 |
| ∆M65 | 4,392±4,473 | 1.001 (1.000–1.002) | 0.130 |
| HMGB-1 level, ng/mL | |||
| At 1 h | 35.3±20.8 | 0.574 (0.313–1.050) | 0.072 |
| At 4 h | 49.8±26.1 | 1.087 (1.875–1.351) | 0.452 |
| ∆HMGB-1 | 14.5±22.9 | 1.383 (1.062–1.801) | 0.016 |
| Donor variables | |||
| Age, years | 43.1±14.6 | 0.996 (0.952–1.041) | 0.851 |
| Female | 23 (51.1) | 1.086 (0.562–2.098) | 0.806 |
| DCD | 18 (40.0) | 1.084 (0.181–6.503) | 0.930 |
| Smoking history | 26 (57.8) | 3.557 (0.725–17.710) | 0.121 |
| Cause of death: head trauma | 9 (20.0) | 0.550 (0.069–4.406) | 0.573 |
a, continuous variables are expressed as mean ± standard deviation and categoric variables as number (%); b, transplanted group = the control + primary graft dysfunction groups; c, hazard ratio is reported by increase of each 10 U/L for M30 and M65 and each 10 ng/mL for HMGB-1, respectively. CI, confidence interval; DCD, donation after cardiac death; HMGB-1, high mobility group box; ∆, refers to the difference between the value at 4 hours of ex vivo lung perfusion and the value at 1 hour of ex vivo lung perfusion.