Figure S1.

Study flow diagram. Publications of primary RCTs of blood pressure targets (24-29,42-44,104-107); publications of RCTs that examined efficacy or comparative effectiveness of antihypertensive drugs in 1970–1989 (108-114), 1990–1999 (41,115-135), 2000–2002 (136-152), 2003–2005 (153-174), 2006–2009 (175-190), 2010–2014 (191-207); publications of reviews (3-5,30,31,33-38,40,50,90,93,208,209); publications of guidelines published in 2010–2014 (59,60,62-66,94,95,97,210-213) and in 2015–2018 (51-56,61,87,96,98,214-217).