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. 2018 May 22;15(8):832–839. doi: 10.7150/ijms.23270

Figure 5.

Figure 5

PSN-A modulates Bcl-2 family proteins and inhibits STAT3 signaling. (A) LNCaP and DU145 cells were treated with 0, 25 and 50 nM PSN-A for 24 h. Total proteins were extracted and subjected to immunobloting for the expressions of Bax, Bcl-2, cleaved caspases-3 and PARP-1. β-actin was used as loading control. (B) LNCaP and DU145 cells were treated with 0, 25 and 50 nM PSN-A for 24 h. Total cell lysates were extracted and subjected to Western blot for the expressions of SHP-1, SHP-2, PTEN, p-Jak2, Jak2, p-STAT3 and STAT3. β-actin was used as loading control.