Table 5.
SGLT2 inhibitor concentrations in small intestine (ng/g) in rats
| 1 h | 8 h | 24 h | |
|---|---|---|---|
| Ipragliflozin | 729.5±377.2 (2.63±1.48) |
347.6±104.8 (3.89±3.73) |
- a) ( - ) a) |
| Dapagliflozin | 37.9±10.3 (0.71±0.35) |
19.7±6.7 (0.32±0.13) |
ND ( - ) |
| Tofogliflozin | 1356.0±512.6 (7.48±0.97) |
250.1±114.5 * (7.07±3.41) |
- a) ( - ) a) |
| Luseogliflozin | 250.8±178.4 (115.53±82.81) |
- a) ( - ) b) |
- a) ( - ) b) |
| Canagliflozin | 2925.2±1074.2 (12.93±9.88) |
440.1±117.2 * (0.92±0.20) |
325.9±218.0 * (4.05±2.83) |
The values are mean ± SD of the concentrations with their ratios to plasma concentrations in the parentheses.
* P < 0.05, compared with the data at 1hr.
ND: below the limit of detection.
a) The data included 1 or more data of ND.
b) The plasma concentration was below the limit of detection.