Table 2.
Distribution of biomarker concentrations in plasma samples from cases with MPM and controls from Mexico
| Cases | Controls | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Median | IQR | N | Median | IQR | P-valuea | |||
| Mesothelin (nmol/L) | |||||||||
| Males | 63 | 2.21 | 1.37-3.93 | 170 | 0.58 | 0.40-0.87 | <0.0001 | ||
| Age | <70 years | 41 | 2.04 | 1.28-3.77 | 120 | 0.52 | 0.38-0.76 | ||
| ≥70 years | 22 | 2.75 | 2.14-3.93 | 50 | 0.76 | 0.48-1.02 | |||
| Occupational exposure to asbestos | |||||||||
| Never | 4 | 1.10 | 0.66-2.76 | 51 | 0.61 | 0.43-0.85 | |||
| Ever | 59 | 2.29 | 1.56-3.93 | 119 | 0.55 | 0.40-0.89 | |||
| Females | 12 | 2.00 | 1.31-5.40 | 65 | 0.55 | 0.41-0.79 | <0.0001 | ||
| Age | <70 years | 9 | 1.46 | 1.28-3.24 | 48 | 0.55 | 0.41-0.78 | ||
| ≥70 years | 3 | 6.20 | 2.13-9.90 | 17 | 0.59 | 0.31-0.95 | |||
| Occupational exposure to asbestos | |||||||||
| Never | 8 | 1.80 | 1.29-5.40 | 53 | 0.55 | 0.38-0.79 | |||
| Ever | 4 | 2.56 | 1.57-5.01 | 12 | 0.55 | 0.45-0.87 | |||
| Calretinin (ng/mL) | |||||||||
| Males | 62 | 0.93 | <0.45-2.18 | 172 | <0.07 | <0.01-<0.22 | <0.0001 | ||
| Age | <70 years | 40 | 1.00 | <0.31-2.50 | 120 | <0.08 | <0.01-<0.23 | ||
| ≥70 years | 22 | 0.85 | 0.58-1.98 | 52 | <0.06 | <0.01-<0.22 | |||
| Occupational exposure to asbestos | |||||||||
| Never | 4 | 1.41 | <0.74-2.16 | 51 | <0.06 | <0.01-<0.20 | |||
| Ever | 58 | 0.86 | <0.45-2.18 | 121 | <0.08 | <0.01-<0.24 | |||
| Females | 12 | 0.86 | <0.25-1.33 | 68 | <0.22 | <0.10-0.48 | 0.0037 | ||
| Age | <70 years | 9 | <0.35 | <0.24-1.12 | 50 | <0.22 | <0.12-0.48 | ||
| ≥70 years | 3 | 3.09 | 0.97-4.98 | 18 | <0.18 | <0.03-<0.46 | |||
| Occupational exposure to asbestos | |||||||||
| Never | 8 | 1.04 | <0.55-2.16 | 56 | <0.22 | <0.10-0.48 | |||
| Ever | 4 | <0.25 | <0.13-<0.85 | 12 | <0.27 | <0.08-<0.47 | |||
|
Thrombomodulin (ng/mL) |
|||||||||
| Males | 54 | 2.57 | 1.71-3.18 | 124 | 2.30 | 1.84-2.85 | 0.81 | ||
| Age | <70 years | 35 | 2.01 | 1.66-2.90 | 96 | 2.24 | 1.79-2.76 | ||
| ≥70 years | 19 | 3.04 | 1.97-3.41 | 28 | 2.79 | 2.19-3.38 | |||
| Occupational exposure to asbestos | |||||||||
| Never | 3 | 2.84 | 1.72-3.17 | 29 | 2.22 | 1.70-2.87 | |||
| Ever | 51 | 2.53 | 1.67-3.25 | 95 | 2.31 | 1.86-2.83 | |||
| Females | 10 | 2.25 | 1.77-2.43 | 63 | 2.05 | 1.62-2.72 | 0.84 | ||
| Age | <70 years | 8 | 2.07 | 1.59-2.36 | 47 | 2.01 | 1.58-2.51 | ||
| ≥70 years | 2 | 2.50 | 2.27-2.73 | 16 | 2.26 | 2.06-3.14 | |||
| Occupational exposure to asbestos | |||||||||
| Never | 6 | 2.10 | 1.77-2.30 | 51 | 2.05 | 1.66-2.72 | |||
| Ever | 4 | 2.33 | 1.82-3.19 | 12 | 2.09 | 1.26-2.66 | |||
aMesothelin and thrombomodulin concentrations were compared using the Wilcoxon rank-sum test, calretinin concentrations were compared using the Peto-Prentice test. IQR: interquartile range; '<' indicates percentiles below the limit of detection (LOD)