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. 2018 Jun 13;15(9):953–960. doi: 10.7150/ijms.24146

Figure 5.

Figure 5

The effects of different doses of minocycline (20-60 mg/kg) upon DCA (8.3 mg/kg)-induced scratching. Mice were pretreated with saline or minocycline (20 mg/kg and 60 mg/kg) 20 min before DCA administration. The number of scratches was then counted for 40 min in each group. Minocycline reduced DCA-induced scratching behavior, in a dose-dependent manner. Between-group comparisons for each group were performed by ANOVA, followed by the Dunnett's test (**P < 0.01; ***P < 0.001; the Saline+DCA group served as the reference group).