Table 2.
Testicular and epididymal weight and morphological changes of seminiferous tubules in the control, Dextromethorphan only and treatment groups: Control, Dextromethorphan only (DXM), Dextromethorphan+Drug withdrawal (DW60), Dextromethorphan + Diazepam (DD60), Dextromethorphan + GABA standard (DG60) and Dextromethorphan+Pre-germinated brown rice (DP60)
| Parameter | Control | DXM | DW60 | DD60 | DG60 | DP60 |
|---|---|---|---|---|---|---|
| Testicular weight/Body weight | 0.47±0.01 | 0.59±0.01*** | 0.45±0.01 | 0.48±0.01 | 0.46±0.02 | 0.43±0.01 |
| Epididymal weight/Body weight | 0.14±0.01 | 0.09±0.01*** | 0.14±0.01 | 0.15±0.01 | 0.15±0.01 | 0.14±0.01 |
| Separation of germinal epithelium (%) | 11.61±0.67 | 22.60±1.25*** | 13.31±0.98 | 14.54±1.73 | 12.48±0.86 | 12.16±0.76 |
| Vacuolization (%) | 3.16±0.14 | 5.16±0.32*** | 3.32±0.28 | 3.93±0.15** | 3.19±0.09 | 3.07±0.11 |
| Luminal sloughing of germ cells (%) | 0.51±0.04 | 1.31±0.18** | 0.50±0.06 | 0.60±0.10 | 0.50±0.05 | 0.51±0.06 |
| Irregular tubule (%) |
6.13±0.30 | 9.84±0.57*** | 6.91±0.19 | 10.53±0.98*** | 6.85±0.29 | 6.38±0.35 |
| Atrophy (%) | 0.10±0.05 | 0.29±0.07* | 0.14±0.03 | 0.14±0.03 | 0.11±0.04 | 0.11±0.03 |
Values are expressed as mean±SEM. Statistical significance is indicated as *p<0.05, **p<0.01 and **p<0.001 in comparison with control group