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TNF-α signaling pathway was found to be inhibited in osteosarcoma. (A) Top 10 signaling pathways discovered by KEGG were displayed basing on the significantly differentially expressed myokines. (B) Significant changes in myokine expression levels were observed in osteosarcoma compared to cancellous bone in the downstream of TNF signaling pathway(ko04668). Hit myokines are labeled with grey boxes.
