Table 3.
Diagnostic efficiency of each method in CRC detection.
| Sensitivity (%) |
Specificity (%) |
AUC |
||||
|---|---|---|---|---|---|---|
| Value | 95% CI | Value | 95% CI | Value | 95% CI | |
| FOBTa | 61.4 | 50.9–70.9 | 70.3 | 59.1–79.5 | 0.658 | 0.578–0.723 |
| CEA | 35.0 | 27.1–43.7 | 62.6 | 53.8–70.7 | 0.485 | 0.411–0.559 |
| Ca-199 | 17.9 | 12.1–25.6 | 55.7 | 48.9–64.1 | 0.353 | 0.283–0.423 |
| mSEPT9 | 61.8 | 53.0–69.9 | 89.6 | 83.0–93.8 | 0.757 | 0.701–0.807 |
| FOBT + mSEPT9a | 84.1 | 75.1–90.3 | 62.2 | 50.8–72.4 | 0.807 | 0.740–0.875 |
FOBT, fecal occult blood test; CEA, carcinoembryonic antigen; Ca-199, carbohydrate antigen-199; AUC, area under the ROC curve; 95% CI, 95% confidence interval; mSEPT9, methylated Septin9; CRC, colorectal cancer.
aFOBT information was missing among 86 subjects.