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. 2018 Jul 2;9:281. doi: 10.3389/fpsyt.2018.00281

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Copyright © 2018 Renard, Rushlow and Laviolette.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of microinfusion of muscimol (MUS) within the PFC on adolescent THC-induced behavioral abnormalities. (A) Adolescent THC pretreated rats displayed short-term memory deficits. Microinfusions of MUS within the PFC restored short-term memory deficits as compared to intra-PFC VEH controls in the object recognition task during adulthood. (B) Adolescent THC pretreated rats displayed deficits in social motivation (left) and social cognition (right). Microinfusions of MUS within the PFC improved social motivation (left) and social cognition (right) as compared to intra-PFC VEH controls in the social interaction task during adulthood. (C) Adolescent THC pretreated rats displayed increased anxiety. Microinfusions of MUS within the PFC decreased anxiety levels as compared to intra-PFC VEH controls in the light dark box task during adulthood. (D) Adolescent THC pretreated rats displayed hypolocomotor activity. Microinfusions of MUS within the PFC normalize locomotor activity as compared to intra-PFC VEH controls in the open field task during adulthood. Figure modified from Renard et al. (148). *P < 0.05; **P < 0.01.