Figure 4.
Donor-derived HO-1hi immature dendritic cells (imDCs) are more efficient in modulating allograft rejection and prolonging heart allograft survival. Untreated, cobalt protoporphyrin (CoPP)-pretreated, or SnPP-pretreated BALB/c mouse-derived imDCs (5 × 106) were injected intravenously into C57BL/6 recipients 7 days before cardiac transplantation. As a control, recipient mice received no cell transfusion, and only injection with the same volume of PBS. (A) The kinetics of cardiac allograft survival rates for all study groups are shown (**P < 0.01, untreated imDC group vs. both control group and SnPP-pretreated imDC group; CoPP-pretreated imDC group vs. untreated imDC group; n = 6–9 per group); (B) hematoxylin and eosin staining was performed to assess the pathological changes in allografts harvested at day 7 posttransplant in the PBS control group, untreated imDC group, and CoPP-pretreated imDC group (a–c: magnification, 100×; d–f: magnification, 200×).