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. 2018 May 18;293(27):10675–10691. doi: 10.1074/jbc.RA117.001297

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Figure 4. — Effect of EETs, DHETs, EET isomers, and EET analogs on [Ca²⁺]_i in HEK293 cells expressing human GPR40. A, comparison of the activity of 11,12-, 14,15-EETs, and -DHETs. B, comparison of 11,12- and 14,15-EET and their thiirane analogs. C, comparison of the cis- and trans-isomers of 11,12- and 14,15-EETs. D, effect of 11,12-EET in the absence and presence of 1 μm arachidonic acid and effect of arachidonic acid in the absence and presence of 0.1 μm 11,12-EET. Each value represents the mean ± S.E. for n = 4. veh, vehicle.